The Progress of Gene Networks
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This work was supported by a grant from the National Science Foundation of China (39770420,30100115) and the National Science Foundation of Zhejiang Province (300255).

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    Abstract:

    The progress of molecular biology attributes the complexity of life to the interaction of mass genes ,and thus the traditional descriptive method in biology and analysis by disassembling faces the cruel challenge. The application of DNA chip and molecule array enables scientists to monitor the massively parallel expression of genes,which lead to emphasis of gene networks as a systematic,quantitative method in the research of life science.Based on the crossing of subjects on molecule biology, nonlinear maths and informatics,the object of gene networks is to construct the dynamics model which has nonlinear traits such as robustness,hierarchy and so on.The massive data of gene expression combined with fit algorithm can help scientists establish the topology of the interactions,by which the system behavior can be simulated. Contrariwise,the model established can direct the further experiments.To study gene networks the computer and Internet resource are very important.The study of gene networks will play an important role in the post-genome research.

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PENG Hua-Zheng, PAN Jian-Wei, ZHU Mu-Yuan. The Progress of Gene Networks[J]. Progress in Biochemistry and Biophysics,2001,28(6):815-818

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History
  • Received:January 10,2001
  • Revised:February 23,2001
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