The potential importance of ubiquitin-proteasome pathway (UPP) as a mechanism for a series of processes including cell cycle progression, apoptosis, immune and inflammatory responses, tumorigenesis and metastasis, as well as some genetic and neurodegenerative diseases has long been recognized. Nevertheless, roles of UPP in different reproductive events are only beginning to be clarified. UPP has recently been shown to be related to a variety of male reproductive events, such as spermatogenesis, spermiogenesis, as well as many female reproductive events, including tissue remodeling of the endometrium during normal menstrual cycle and early pregnancy and the degradation of the steroid receptors. Combined with domestic situation, the emerging roles of UPP in reproductive tissues are also presented.