To investigate new genes related to renal damage of diabetic hypertension rats for exploring its mechanism,the model of diabetic hypertension rats was established by streptozotocin(STZ) injection. Urine protein of this model rats continued positive and ultrastructure of their renal cortex changed. Fluorecence-labelled differential display reverse transcription polymerase chain reaction and Northern blot were used to isolate and identify the genes that showed transcription changes in the renal cortex between the unitary hypertension and diabetic hypertension rats.Four differential fragments were obtained, two of which were novel whereas the other two showed significant similarity with rat amyloidogenic glycoprotein and CDK109 respectively according to the public database of Genbank. Via the application of bioinformatics the altered renal mRNA expression of these genes associated with diabetic hypertension suggested that they were the candidates for a role in the development of the nephropathy.