Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane. Caveolae, a type of lipid rafts, is characterized by high levels of cholesterol, sphingolipids and proteins, and is identified by the presence of the protein caveolin. The structure and component of lipid rafts is used of reciprocity and comformational change between proteins. Lipid rafts are associated with signal transduction and cellar proteins movement. The disfunction of lipid rafts is related to some diseases such as infection, heart disease, cancer, muscular dystrophy and prion protein diseases.