Neurodegenerative disease is a kind of neural system disease which is characterized by degenerative pathological changes of neuron, the consequent behavioral abnormal and even individual death at last. Drosophila, with uniquely powerful molecular genetics, has been a competent model to research human neurodegenerative disease. Screening the genes of Drosophila could not only define the molecular pathway that underlies the neurodegenerative process, but also provide valuable drug targets by consequently studying the control genes and gene products. All of these will uncover the novel means of preventing and curing human neurodegenerative disease.