This work was supported by grants from The National Natural Sciences Foundation of China (10075007), Hebei Provincial Nature Science Foundation (102001) and Doctoral Fund of Hebei Province (00547001D).
The stochastic master equation approach to molecular motor's directed motion is used and a periodic one-dimensional four-state stochastically unequal interval hopping model is studied. The drift velocity V, the diffusion constant D and the randomness parameter r of the steady state are all be obtained. By comparing the simulated curve with experiment about drift velocity V, diffusion constant D and randomness parameter r versus [ATP] and external load F, the kinetic behaviors of a molecular motor under external load F are qualitatively analyzed.
ZHAN Yong, WU Wei-Xia, ZHAO Tong-Jun, GUAN Rong-Hua, MEI Jun-Ping. A Stochastically Unequal Interval Four-state Hopping Model of Molecular Motor[J]. Progress in Biochemistry and Biophysics,2003,30(3):416-421
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