Genetic vaccines were introduced less than a decade ago, but have already applied to a wide range of that fight off infectious, immunological, malignant diseases, and some genetic vaccines have been in clinical trials. Tumor genetic vaccines can break the immune tolerance, activate the immunogenicity, and induce the humoral and cellular responses to tumor cells. The anti-tumor genetic vaccines have proved to be effective prophylactic and curative vaccination against tumor. Progress in anti-tumor genetic vaccines is very rapid, including tumor-associated-antigens-based completed, epitope, idiotope determinants DNA vaccines, fusion DNA vaccines, RNA self-replicating vaccines, dendritic cell-based tumor vaccines etc. Meanwhile, the molecular mechanisms and the problems of the anti-tumor genetic vaccines also attract the scientists in this field.