A New Oxygen-binding Globin: Neuroglobin

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A New Oxygen-binding Globin: Neuroglobin
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Fund Project:This work was supported by grants from The Special Funds for Major State Basic Research of China (G1998040813), Key Project of The Chinese Academy of Sciences (KZCX1-09-01) and Haibei Alpine Meadow Ecosystem Research Station Found, The Chinese Academy of

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Abstract:

Neuroglobin (NGB) is a newly discovered member of the hemoglobin family that reversibly binds O₂ and is expressed predominately in vertebrate brain. NGB is a monomer composed of 151 amino acids, with high oxygen affinity. It is of ancient evolutionary origin. Hithertos, it has been proved to associate with oxygen storage, transport and neuron protection. NGB gene expression is mediated by at least 2 signal transduction pathways. The discovery of NGB provides a new direction for treating patients with strokes and other hypoxia-related diseases.

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ZHAO Tong-Biao, CHANG Zhi-Jie, ZHAO Xin-Quan. A New Oxygen-binding Globin: Neuroglobin[J]. Progress in Biochemistry and Biophysics,2003,30(6):844-846

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Received:April 22,2003
Revised:May 28,2003
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