In the early 1990's, Iijima et al. separated a protein, which has the activity of antifungal to suppress the growth of C.albicans, from the hemp musca larva blood lymph. So far, more than 150 kinds of peptides which are characteristic of antifungal have been discovered. With the number of antifungal peptides discovered increasing, researchers have been studying the mechanism of antifungal peptides. The way the antifungal peptides function is mainly as follows: preventing and damaging the synthesis of cell wall; interacting with the membrane to form pores; causing the important inclusions to release; interacting with the important organelles such as mitochondrion and nucleic acid macromolecules in the fungi cell, leading to the death.
ZHANG Jie, ZHANG Shuang-Quan. Advance in The Research of The Function of Antifungal Peptides Against Fungus[J]. Progress in Biochemistry and Biophysics,2005,32(1):13-17
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