A new lectin extracted from lablab can maintain the multipotential of hematopoietic stem/progenitor cells in vitro for a long time in addition to its hemagglutination property. This new lectin FRIL (Flt3-rectptor interacting lectin) was purified from Dolichos lablab, its biological speciality was identified and its receptors were located on hematopoietic stem/progenitor cells. When CD34⁺ cells were cultured in the presence of this lectin or its counterpart FL, within the 28 days of culture, FRIL can keep more cells in G0/G1 phase (beyond 80%) and 1.5 fold colony forming cells more than FL does after 14-day's culture. So, it is concluded that FRIL maintain HSC/HPCs self-renewal property by halting its cell cycles.