Bromodomain is an evolutionally conserved domain and is identified in proteins strongly implicated in signal-dependent gene transcription regulation. BRD7, a novel bromodomain gene, has been cloned by cDNA RDA (cDNA Representational Difference Analysis) in 1999. The GenBank accession number is AF152604 or AF152605. eMotif analysis revealed that BRD7 protein contains a conserved bromodomain and several important phosphorylation sites. Multiple sequence alignment program showed high ratio identity between BRD7 protein, protein Celtix-1 and musculus bromodomain-containing protein BP75. Over expression of BRD7 in Nasopharyngeal carcinoma (NPC) cells can inhibit cell proliferation and cell cycle progression from G1 to S phase, and can partly inhibit the aberrant growth of NPC cells. In order to further address the signal pathway and the possible functions of BRD7 gene, function analysis of BRD7 gene was performed through three different cellular physiology levels including up- and down-stream, interplay issues of BRD7 gene.