With a persisting development in tumor targeting viruses as a special anti-tumor agent and therapeutic gene vector for the recent years, a number of highly effective, targeting virus vectors have been exploited, which still did not satisfy the requirement for cancer targeting therapy in clinic. However, it has remained unsolved in how to effectively and veraciously deliver these targeting viruses to the tumor tissues. The cytokine-induced killer cells (CIK) as one of the cell therapy methods in tumor therapy have been widely applied in clinic. Recently, scientists have used the CIK cell as a vehicle to successfully carry viruses to the tumor tissues, which showed a robust anti-tumor effect. Meanwhile, the experiment method made a great breakthrough in systemic virus delivery and data figured a potential application for the treatment of cancers.