Protein quantitative research has become a hot topic in proteomics and a main approach to discover biological protein functions. The technique based on isotope labeling and biological mass spectrometry analysis is one of the most commonly used strategies for protein quantification. In recent years, with the development of mass spectrometry techniques, inductively coupled plasma mass spectrometry (ICP-MS) becomes a powerful tool for research and measurement of elements, and may be enabling new insights and broad application in protein quantification. The advance of ICP-MS based techniques in the research of protein quantification was reviewed.