Inflammation is the normal host tissue response to infection and injury. However uncontrolled and unresolved inflammation contributes to a range of acute and chronic human disease. Recent results have demonstrated several new families of lipid mediators, derived from eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) of n-3 serial fatty acid, that including resolvins and protectins, to be both anti-inflammation and proresolving. Biosynthesis, anti-inflammatory action and mechanism of these new proresolving lipid mediators were described in order to complete the anti-inflammatory mechanism of n-3 polyunsaturated fatty acid and offer exciting new potential for therapeutic control.