In this paper, a novel scale-free network construction algorithm based on reconnection method was proposed. The regulatory node of the new node will be reselected according to the reconnection method. The probability of reconnection depends on the gamma in the power-law distribution model parameters. The constructed network with our algorithm was used for simulating gene expression profiles using differential equation model with two heuristic search algorithms, GA and PSO, and new algorithm GFA to optimize the criterion. The candidate old node can be selected as regulatory node based on the number of links the old node already has. The network in the experiment was testified using log-log graph. And the simulated gene expression profiles were also tested with three different well developed algorithms' software available free from internet by reconstructing the network. PPV and Se of the links were calculated and visualized. A part of the results and the full version program written by java could be downloaded from our website: http://ccst.jlu.edu.cn/CSBG/ourown/.