Review: Advances in Relationship Between Class Ⅲ PI3K Complex and Autophagy

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Review: Advances in Relationship Between Class Ⅲ PI3K Complex and Autophagy
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China(30770491, 30970655), State Key Laboratory Special Fund (2060204) and Ministry of Education, China for Doctor Training Unite (20091106110025)

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Abstract:

Class Ⅲ phosphoinositide 3-kinase (class Ⅲ PI3K), which specifically phosphorylate PtdIns to generate PtdIns3P, plays a vital role in autophagy and vacuolar sorting pathways by forming Class Ⅲ PI3K(PI3KC3) complexes with a variety of regulatory proteins. Proteins that compose PI3KC3 complex, namely, PI3K, p150, Beclin 1, ATG14L, UVRAG, Bif-1 and Rubicon are conserved in evolution. In addition, neurodevelopment, situs inversus totalis and development of tumor are found to closely related to these members.

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WU Pa, XU Cai-Min. Review: Advances in Relationship Between Class Ⅲ PI3K Complex and Autophagy[J]. Progress in Biochemistry and Biophysics,2012,39(3):210-216

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Received:August 22,2011
Revised:November 28,2011
Accepted:
Online: December 20,2011
Published: March 20,2012

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