This work was supported by grants from The Program for New Century Excellent Talents in University (NCET-10-0879), The National Natural Science Foundation of China (11172338), The Key Science and Technology Program of CQ CSTC (2009AA5045), The Scientific Research Foundation for The Returned Overseas Chinese Scholars, State Education Ministry, The Sharing Fund of Chongqing University's Large-scale Equipment, and The Fundamental Research Funds of The Central Universities (CDJXS112300)
Injury of peripheral nerve is very common in trauma, which easily causes partial or whole damage to peripheral nerves and will further result in function loss or other neurological diseases. With the development of technology, the treatment efficacy of peripheral nerve injury has been improved significantly. However, it is still very difficult to obtain the morpgologic and functional regeneration. Slow rates of nerve regeneration and functional recovery are still the difficulty in clinics. Electrical stimulation is convenient, non-invasive and with few side effects. More and more researchers have paid attention to using stem cells combined with electrical stimulation to repair injured peripheral nerve. In this study, the applications and advancement of using stem cells combined with electrical stimulation in injured peripheral nerve regeneration were comprehensively reviewed. The possible mechanisms of them were further discussed. Particularly, the difficulties of using stem cells combined with electrical stimulation to repair injured peripheral nerve were analyzed. Prospect along this direction was also discussed.
ZHAO Peng-Cheng, LV Yong-Gang, ZOU Yang, ZHANG Xiao-Mei, CHEN Guo-Bao, YANG Li. Research Advancement on Injured Peripheral Nerve Regeneration by Stem Cells Combined With Electrical Stimulation[J]. Progress in Biochemistry and Biophysics,2012,39(6):540-547
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