This work was supported by grants from National Basic Research Program of China (2010CB945500, 2012CB966300, 2009CB941100), The National Natural Science Foundation of China (30870805, 90919002) and The Natural Science Foundation of Shanghai City (08dj1400503)
Cellular senescence is a process that leads to a growth arrest. Some of these cells are cleared after being in a state of alive but lose the ability to divided long time, while some cells (named senescent cell) accumulate in aging tissues, secrete agents that stimulate the immune system and cause low-level inflammation, which may disrupt nearby tissue structure and function even promote cancer progression. A recent report in Nature by Baker et al. introduced a method of delaying aging process by clearing senescent cells in mice. The findings raise the prospect that any therapy that rids the body of senescent cells would protect it from the ravages of aging.
WANG Pu, CHEN Lu-Ping, LI Qing-Quan, TANG Qi-Sheng, SHEN Yi-Wen, ZHU Jian-Hong. Cellular Senescence and Senescent Cell[J]. Progress in Biochemistry and Biophysics,2012,39(3):257-263
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