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Reconstruction of Whole Cell Network and Design of Cell Factory
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Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences,Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences,Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

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This work was supported by grants from National Basic Research Program of China (2011CBA00804), The National Natural Science Foundation of China (31070037, 31370829), Tianjin Research Program of Application Foundation and Advanced Technology (11ZCZDSY08400) and The National Hi-Tech Research and Development Program (2012AA023402)

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    Abstract:

    Based on the maturity of the researches of various kinds of Omics networks, integrated cell network which integrates Omics networks will greatly improve the prediction ability of biological phenotype, and will become a powerful weapon of metabolic engineering decisions. After expounding that integrated cell network should be considered in the design of cell factory, we gave a review about reconstruction, analysis, and design methods of integrated cell network. We also introduced several aspects of databases, software platforms, parallel computing which involved in the research of integrated cell network.

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XU Zi-Xiang, ZHENG Ping, SUN Ji-Bin. Reconstruction of Whole Cell Network and Design of Cell Factory[J]. Progress in Biochemistry and Biophysics,2014,41(2):105-114

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History
  • Received:October 29,2012
  • Revised:June 26,2013
  • Accepted:July 04,2013
  • Online: February 21,2014
  • Published: February 20,2014
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