Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University, Changsha, 410078, China; 2)Department of Stomatology, Xiangya Second Hospital, Central South University, Changsha 410011,China,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University,Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Carcinogenesis of Ministry of Health, Cancer Research Institute, Central South University

This work was supported by grants from The National High Technology Research and Development Program of China(863)(2012AA02A206), 111 Project (111-2-12), the National Natural Science Foundation of China (81171930, 81171931, 81172189, 81272254, 81272298, 181372907, 91229122), Hunan Province Natural Sciences Foundation of China (14JJ1010)