Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Tianjin Medical University General Hospital, Tianjin 300052, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Tianjin Medical University General Hospital, Tianjin 300052, China,Nanotechnology Research Institute of Materials College of Tianjin University
This work was supported by grants from National High Technology Program of China (2012AA022603), Doctoral Base Foundation of Educational Ministry of China (20120032110027), National Natural Science Foundation of China (51373117) and Key Project of Tianjing Natural Science Foundation(13JCZDJC33200)
Recently, liposomes have gained attention as a promising tool for drug and gene delivery. However, their applications have been constrained by their poor stability, aggregation and difficult to functional. Using amphiphilc conjugated linoleic acid modified polylysine (PC) and cholesterol, we developed a novel polymeric liposomes (PLs). These PLs retained the advantages of conventional liposomes (CLs), and overcome the above disadvantages of CLs. In addition, PEG chains coated on the PLs surface can prolong their circulation time in the blood. These results suggest that the PLs were nano-sized, achieved a sustained release of drugs, showed limited cytotoxicity and increased uptake in LN229 glioblastoma cells.
WANG Sheng, WANG Hua-Quan, WANG Han-Jie, SU Wen-Ya, WANG Liang-Liang, PENG Yao, HAN Lei, CHANG Jin.Review: The Research of Anti-Tumor Drugs Long Circulating Polymeric Liposomes[J]. Progress in Biochemistry and Biophysics,2013,40(10):1063-1069
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