Autism spectrum disorders (ASD) is a widely developmental disabilities, with the main clinical features including barriers to social interaction, verbal and non-verbal communication defects, narrow interests and stereotyped behaviors. The present article aims to introduce some information about language impairment of autism, including relative researches published from 1986 to the current time on the neural mechanisms underlying autism's language impairment. This issue was addressed from brain structural, brain functional asymmetry, and the influence of handness, and at last, a summary was given based on the literatures, which is that the autism has an atypical right language lateralization both of structural and functional, there also exist available evidence that atypical handness is associated with poorer neurocognition or anomalous cerebral asymmetries. This article will be helpful for diagnosis and therapy to the autism in the future and will facilitate the research of ASDs under Chinese culture.