The research on nanozyme which is a novel enzyme mimic based on nanomaterial, is becoming a rapidly emerging field since ferromagnetic nanoparticles with intrinsic peroxidase-like activity was first reported in 2007. Many nanozymes with different morphologies, sizes and components are found to have intrinsic enzyme-like activities and their catalytic mechanisms are systematically investigated. Nanozyme demonstrates high efficient activity, stability and low cost by preparation at large scale. Therefore, nanozymes have promising and multiple applications in many important fields, such as biomedicine, chemical industry, food, agriculture and environment. The discovery of nanozyme not only promotes the basic research in nanotechnology, but also expands the applications of nanomaterials. This review will introduce the latest research progresses in the field of nanozyme.