Using yeast, nematodes, fruit flies, mice and other model organisms, many studies have shown that cellular senescence closely associated with redox events．Intracellular level of GSSG is increasing along with aging, while GSH and NADPH levels decrease．Redox changes will directly affect protein function, especially redox-sensitive cysteine-containing proteins, and further affect signal transduction and cell fate．Redox imbalance may be an important factor in aging process．In this review, we will summarize the latest progress in aging concerning redox balance, redox signal transduction and oxidative damage, and discuss new strategies in anti-aging and healthy aging, such as maintenance of redox balance, systemic regulation of redox status and individual redox treatment．