FKBP12.6 Regulates The Secretion of Adrenal Chromaffin Cell in Mice

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FKBP12.6 Regulates The Secretion of Adrenal Chromaffin Cell in Mice
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Affiliation:National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy,State Key Laboratory of Biomembrane Engineering and the Centre for Life Sciences, Institute of Molecular Medicine, Peking University,National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy,National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy,State Key Laboratory of Biomembrane Engineering and the Centre for Life Sciences, Institute of Molecular Medicine, Peking University,State Key Laboratory of Biomembrane Engineering and the Centre for Life Sciences, Institute of Molecular Medicine, Peking University,National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy
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Fund Project:This work was supported by grants from National Basic Research Program of China (2011CB809104) and The National Natural Science Foundation of China (31271228)

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Abstract:

FK506 binding protein 12.6 (FKBP12.6), a protein that binds to and regulates the ryanodine receptor type 2 (RyR2) Ca²⁺ release channels, may act as an important regulator of catecholamine secretion. In the present study, the role of FKBP12.6 in the control of chromaffin cell exocytosis has been investigated using FKBP12.6-null mice. The results showed that FKBP12.6 was expressed in mouse chromaffin cells; deletion of FKBP12.6 did not change the depolarization induced Ca² current and exocytosis. However, deletion of FKBP12.6 resulted in an enhanced caffeine-induced global Ca² transient and larger caffeine-induced exocytosis in chromaffin cells of mice. These results indicate that FKBP12.6 is involved in catecholamine secretion through regulation of Ca² release channel in mouse chromaffin cells.

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YUAN Qi, GUO Ning, GU Lei, WANG Jun, WANG Li, ZHOU Zhuan, JI Guang-Ju. FKBP12.6 Regulates The Secretion of Adrenal Chromaffin Cell in Mice[J]. Progress in Biochemistry and Biophysics,2014,41(5):449-455

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Received:March 13,2014
Revised:April 16,2014
Accepted:April 16,2014
Online: May 22,2014
Published: May 20,2014

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