Among many odes, I like the "Song of Yangtze River " very much: "you come from the ancient times, …you are the source of endless". At the 40th anniversary of the Progress in Biochemistry and Biophysics, I would like to sing my heart song, "Ode to the Brain". The Human Brain is like the long river of history. It from ancient to today, and will from today to the future. Human brain is the most fine, most complex, most beautiful and the most successful organ created by the long natural selection process. It is the greatest miracle of intellectual evolution. It is the source of human intelligence, is the human spiritual home. The wisdoms of the human brain created and promote the formation of the social inheritance of human knowledge and civilization. Until now, we still don't know how the human brain works. We believe that the brain functional connectomics may be a key to crack the secret of the brain.