Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,the Third Xiangya Hospital, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University

This work was supported by grants from the National Natural Science Foundation of China (81172189, 81272298, 81372907, 81301757, 81472531, 81402009, 81528019, 81572787), the Hunan Province Natural Sciences Foundation of China (14JJ1010, 2015JJ1022)