NF-E2-related factor-2(Nrf2) is an essential transcription factor that regulates an array of detoxifying and antioxidant defense genes expression in the liver. Oxidative stress could represent a common link between different forms of diseases. Nrf2 activation is initiated by oxidative or electrophilic stress, and induces its target genes by binding to the antioxidant response element (ARE)aimed at cytoprotection. Studies from several animal models suggest that the Nrf2-ARE pathway collectively exhibits diverse biological functions against viral hepatitis,drug-induced liver injury,alcoholic and nonalcoholic liver disease and cancer via target gene expression. The relevant literatures concerning the role of the Nrf2 and its pathway in protecting against hepatic injury were summarized and we will discuss the potential application of Nrf2 as a therapeutic target to prevent and treat liver diseases.