The Electrophoresis on Microfluidic Chips and Its Application in Forensic Science

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The Electrophoresis on Microfluidic Chips and Its Application in Forensic Science
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Affiliation:People’s Public Security University of China,Institute of Forensic Science, Ministry of Public Security,Institute of Forensic Science, Ministry of Public Security,Institute of Forensic Science, Ministry of Public Security
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Fund Project:This work was supported by grants from Special Program of Basic Research for the Central Public Welfare Research Institutes(2015JB005), Research Project of Ministry of Public Security (2014JSYJA011)

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Abstract:

After optimizing the conditions of surface modification, sieving matrix, electric field strength of separation, injection mode, electrophoresis temperature, injection time and so on, forensic DNA samples included 15 STR loci can be separated on Brofloat glass electrophoresis chip, using electrophoresis apparatus equipped with confocal laser induced fluorescence detection system. The optimized electrophoresis system conditions were obtained and DNA samples were successfully separated within 8min. The microchip electrophoresis system has good prospects in the rapidly forensic DNA analysis.

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HAN Jun-Ping, SUN Jing, ZHUANG Bin, LIU Peng, ZHAO Xing-Chun, LI Wan-Shui, JI An-Quan, YE Jian, LIU Yao, LI Cai-Xia. The Electrophoresis on Microfluidic Chips and Its Application in Forensic Science[J]. Progress in Biochemistry and Biophysics,2015,42(12):1128-1135

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Received:June 19,2015
Revised:September 13,2015
Accepted:November 20,2015
Online: December 18,2015
Published: December 20,2015

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