Cardiovascular disease is the main disease of adult death in China. The abnormal lipid metabolism is an independent risk for cardiovascular disease. So it has important theoretical significance and clinical practical value to explain the role and mechanism of lipid metabolism abnormality in the development of cardiovascular disease. In this issue, we reviewed the new progress in the study of lipid composition and lipid metabolism, and the protective effects of glycine on cardiovascular disease. Additionally, we also showed the research results about the roles and molecular mechanisms of PCSK9/LDLR pathway, small molecule mimic peptide of human apoE (EpK), polyunsaturated fatty acid, adiponectin, LXR α-ABCA1 pathway and probucol in lipid metabolism by Chinese scholars. In order to let more people know the lipid metabolism, to understand the complex mechanism of cardiovascular disease and the research status in recent years.