Advance of Animal Models for Preeclampsia
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1. Hunan Agricultural University; 2.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT),Hunan Agricultural University,Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT),Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences(SIAT)

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This work was supported by grants from The National Natural Science Foundation of China (81571445) and Shenzhen Research Foundation for Basic Research (JCYJ20150521094519488)

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    Abstract:

    Preeclampsia (PE) is a severe pregnancy syndrome with multi-organ vascular dysfunction and classical symptoms, such as, maternal hypertension, proteinuria, glomerular endotheliosis and insufficient trophoblastic invasion. Although quite bit of animal models have been established for PE study, different animal models have both advantages and disadvantages. To date, there is still no one ideal animal model for PE study. This is also the reason that the etiology of PE is still unknown, and no effective treatments are available for PE. In the light of providing references for selecting the right animal model for investigations and establishing ideal animal models, we summarized the characteristic of different animal models for PE in this review.

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XIAO Zhong-Lin, YANG Qing, ZHANG Jian, FAN Xiu-Jun. Advance of Animal Models for Preeclampsia[J]. Progress in Biochemistry and Biophysics,2016,43(6):563-569

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History
  • Received:January 14,2016
  • Revised:March 25,2016
  • Adopted:April 14,2016
  • Online: June 21,2016
  • Published: September 20,2016
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