An important class of mitochondrial function protein is referred to as an iron-sulfur cluster protein (Isc) family, which plays a vital role in the cellular energy metabolism, electron transfer, substrate-binding and activation, iron-sulfur storage, enzymatic reaction and gene regulation. Dysregulation in either the Isc assembly or transport processes would give rise to a deteriorative effect on both the intracellular iron homeostasis and the functionality of Isc-relevant proteins. Particularly, IscA (molecular mass, ～11 ku) is identified as a highly conserved member of the iron-sulfur protein hesB subfamily that can directly bind to iron ions and iron-sulfur [2Fe-2S] cluster and hence participates in the biosynthesis of iron sulfur cluster proteins. Thereby, IscA is postulated to display a paramount function in the iron-sulfur cluster assembly and cascade reaction system. Curiously, it is worth mentioning that two seemingly similar but different discoveries on the topic of IscA1 published respectively by Dr. Xie and Dr. Zhang’s groups in 2015, no matter whether they have attracted extensive public attention, unraveled that IscA1 possesses a putative magneto-receptor capability and thus IscA1 has been renamed as MagR/MAR in their papers. In addition, Xie’s group found that IscA could act as a magnetic sensor by means of forming magnetosensor (MagS) complex with Cry. Of crucial importance to notice, the expression of certain magneto-responsive genes in vivo could be regulated by the external magnetic field-stimulated activation of MagR, which would subsequently affect neural activity and the magnetic oriented animal behaviors. Regarding to the unique magneto-sensing function of MagR, the concept for “magnetogenetics” is proposed by Dr. Zhang’s group in combination of the genetic targeting to MagR/MAR with relevant remote magnetic stimulation. In this mini-review, we give a brief introduction into the discovery of MagR/IscA and its homologues together with their high evolutionary conservation, as well as current proceedings of researches on its physiological functions. Furthermore, we proposed an intracellular biomagnetic signaling-responsive mechanism insofar as to provide an explicit explanation of how MagR/IscA1 exerts it intrinsic function in magnetogenetics.