Endocytosis plays important roles in the internalization of micronutrients and turnover of membrane components. Endophilin has always being considered involving in clathrin-mediated endocytosis process. However, it was reported that endophilin marks and controls a clathrin-independent endocytic pathway on Nature in 2015 by two research groups. This review introduces recent advances in endophilin A2 and highlights the functions and mechanisms of endophilin A2 in clathrin-independent endocytosis.