Autoimmune hepatitis (AIH) is a chronic inflammatory disease in which a loss of tolerance of hepatic tissue is presumed. The concanavalin A (Con A)-induced autoimmune hepatitis model in mice is a well established and widely used model for investigating the pathogenesis mechanisms and pathological changes of T-cell dependent liver injury. Janus-activated kinases/signal transducer and activator of transcription(JAK/STAT)signal pathway paly a critical role for intracellular signal transduction in this model. The relevant literatures concerning the mechanism of the IFN-γ/STAT1 signal pathway, IL-4/STAT6 signal pathway and IL-12/STAT4 signal pathway which involved in Con A-induced hepatitis and the role of the IL-6/STAT3 signal pathway and IL-22/STAT3 signal pathway in protecting against Con A-induced hepatitis were reviewed in this article.