Sterol regulatory element-binding proteins (SREBPs) are important nuclear transcription factors, which play critical role in maintaining the balance of lipid metabolism via activating the expression of genes associated with the synthesis and uptake of cholesterol, fatty acids and triglycerides (TG). Recently, it has been shown that SREBPs have a close relationship with inflammation. SREBPs can promote the occurrence and development of inflammation. On the other hand, the inflammation can affect the expression of SREBPs, and thereby lead to dyslipidemia. Further research on the relationship between SREBPs and inflammation may provide novel direction for the prevention and treatment of diseases induced by inflammation and dyslipidemia.