Advances of Succinate Dehydrogenase Mutation in Cancers

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Advances of Succinate Dehydrogenase Mutation in Cancers
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Affiliation:Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University,Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University,Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University,Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University，Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University
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Fund Project:This work was supported by grants from Zhejiang Provincial Top Key Discipline of Biology, Science Foundation of Zhejiang Sci-Tech University (14042107-Y), the Major Science and Technology Special Project of Zhejiang Province (2012C03007-4, 2014C03004), Science and Technology Bureau of Jiaxing (2014AY21021), China

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Abstract:

Succinate dehydrogenase(SDH), a cruciral multiprotein enzymatic complex in the Krebs cycle/transport chain, is located in the cristate of the mitochondria, and composed of A, B, C, and D subunits, which are encoded by SDHA, SDHB, SDHC, and SDHD, respectively. The SDH mutations play a crucial oncogenic role in paraganglioma (PGL, types 1-5), pheochromocytoma (PHEO), renal cell carcinoma (RCC), gastrointestinal stromal tumors (GIST), rare hypophyseal adenomas, and Leigh syndromes. Mutated SDH has been proved to be an important biomarker for diagnosis and a therapeutic target in these cancers. This review summarized and updated a variety of SDH mutations in the neoplasms and discussed the oncogenic role of SDH mutants in proliferation, apoptosis, invasion, migration, tumorgenesis and senescence.

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CAO Zhi-Fa, CHEN Wei-Cai, YANG Pei-Pei, ZHOU Hai-Meng, OU Wen-Bin. Advances of Succinate Dehydrogenase Mutation in Cancers[J]. Progress in Biochemistry and Biophysics,2017,44(1):31-43

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Received:August 18,2016
Revised:December 01,2016
Accepted:December 02,2016
Online: January 17,2017
Published: January 20,2017

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