The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC

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The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC
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Affiliation:Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine;University of Chinese Academy of Sciences,Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine,Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine
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Fund Project:This work was supported by grants from The Key Project of National Natural Science Foundation of China (U1232207), The National Natural Science Foundation of China(11305223), The National Key Research and Development Program of the Ministry of Science and Technology of China (2016YFC0904700), The National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11)

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Abstract:

Mounting evidence indicates the functional importance of alternative splice variations in cancer pathophysiology. The alternative splicing of caspase-9 plays an important role in non-small cell lung cancer (NSCLC). The splicing of caspase-9 gene generates two isoforms caspase-9a and caspase-9b, the ratio of caspase-9a/9b mRNA is pretty lower in a large proportion of human NSCLC tumors. A low caspase-9a/9b ratio, demanded for the tumorigenecity of NSCLC cells, is correlated with the sensitivity of NSCLC cells to anticancer therapy. Thus, the alternative splicing of caspase-9 suggests a novel and crucial distal mechanism in NSCLC and offers promise of a new target for the development of therapeutics in the defense against cancers. Therefore, this review is to summarize the alternative splicing of caspase-9 and its application in the therapy of NSCLC.

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KUANG Yan-Bei, LI Ping, LI Qiang. The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC[J]. Progress in Biochemistry and Biophysics,2017,44(4):293-302

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Received:September 06,2016
Revised:February 27,2017
Accepted:March 01,2017
Online: April 24,2017
Published: April 20,2017

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