The Role and Mechanism of PVT1 in Promoting Human Cancer Progression
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Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University

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This work was supported by grants from The National Natural Science Foundation of China (81372907, 81472531, 81572787, 81672683, 81672993) and the Hunan Province Natural Sciences Foundation of China (2015JJ1022)

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    Abstract:

    In recent years, long non-coding RNA is found to play an important role in the regulation of cell growth, differentiation and other biological functions, and is closely related to the occurrence and development of cancer. The long non-coding RNA gene, PVT1, located in the fragile chromosome 8q24 region has been widely concerned. LncRNA PVT1 is highly expresses in many types of cancer, and act as potential oncogene. It is commonly to form new fusion gene by chromosome break, and translocation, and regulation of tumor cell function; it also interact with MYC and participate in tumor cell proliferation, apoptosis by multiple pathways. However, the specific molecular mechanisms that occur in the development of cancer still need further research. In this paper, we summarized the features, functions and roles of PVT1 in human cancer.

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HE Yi, WEI Fang, ZHANG Shan-Shan, GONG Zhao-Jian, GUO Can, LI Xia-Yu, LI Xiao-Ling, ZHOU Ming, XIONG Wei, LI Gui-Yuan, ZENG Zhao-Yang, SHI Lei. The Role and Mechanism of PVT1 in Promoting Human Cancer Progression[J]. Progress in Biochemistry and Biophysics,2017,44(11):981-989

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History
  • Received:November 14,2016
  • Revised:September 14,2017
  • Accepted:October 20,2017
  • Online: November 20,2017
  • Published: November 20,2017