Methamphetamine is the most widely abused drug in China recent years with more registered people in methamphetamine than that in heroin, and the situation is getting more and more worse. The emotional dysfunction is one of the most important factors to induce relapse in methamphetamine addiction, which caused by the deficit on the structure and function of prefrontal-mesolimbic circuits innervated by monoamine and amino acid neurotransmitters. The present review summarizes the advances in identifying the characteristics of emotional dysfunction manifested in three dimensions: decreased emotional awareness and positive emotion experience, increased negative emotional experience and impaired emotion regulation, and the neural mechanism focused on the prefrontal-limbic circuits underlying the emotional dysfunction. It is found that the irritability and intense anger are the most prominent features of abnormal emotion in methamphetamine addicts even in protracted abstinence periods, which will cause aggressive behaviors and induce relapse. The future studies should pay more attention to identifying the unique features of emotional dysfunction in methamphetamine addiction. Intervention and treatment targeted to emotional dysfunction are also summarized in the present review, which includes pharmaceutical drugs, neuromodulation technology and cognitive and behavioral therapy, etc. With the advances in brain science and computer sciences, future clinical researches will employ neuromodulation methods interfaced on the virtual reality technology integrated multiple sensory emotional information to treat the emotional dysfunction in methamphetamine addiction.