The success of cancer immunotherapy demonstrates the critical involvement of host immune system on cancer cell killing as well as the feasibility of anti-tumor immunity, whereas the immunosuppressive tumor microenvironment restrains the step forward of cancer immunotherapy. Tumor microenvironment is able to induce tumor metabolic reprogramming and this process leads to: (1) competitive utilization of nutrients between tumor cell and host immune cells; (2) regulation of activation and effector function of immune cells caused by tumor derived metabolites or waste through different modes. Thus, this review focuses on current views of the influence of tumor metabolic reprogramming and relevant metabolites on host immune, in order to provide theoretical basis and new ideas for cancer immunotherapy.