Human viral oncogenesis is a complex process with the multistep nature of oncogenesis. Tumor micro-environmental factors including immune cells and cytokines contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. Interaction between oncoproteins and tumor microenvironment (TME) usually leads to immune suppression, thereby promoting cancer development. In this review, current status and perspectives of the research field in the impact of oncoviral proteins on TME are discussed, including Epstein-Barr virus (EBV), high-risk human papilloma viruses (HPVs), and hepatitis B virus (HBV) respectively.