Tumor immunotherapy has now become a new effective therapy against cancer, as a way to use the patient’s own immune system to achieve anti-tumor effect. However, the presence of inhibitory tumor microenvironment can greatly reduce the effect of immunotherapy. Base on the tumor microenvironment composition, classification and the effect of treatment, we explore ways to deal with the inhibition of tumor microenvironment through radiotherapy, chemotherapy, checkpoints, gene modified immune cells and combination therapy, to make the greatest effect of immunotherapy.