The application of magnetic nanoparticles in the biomedical field has widely utilized in recent years especially in magnetic-mediated hyperthermia for cancer treatment because of their unique magnetic properties, that is, the hysteresis loss induces heat under an alternating magnetic field. So far, the magnetic-mediated hyperthermia as a kind of effective means for the treatment of cancer, has entered the third phase of clinical trial. Therefore, in view of the magnetic nanoparticles itself, it has great significance to optimize size, morphology, composition and surface modification to improve their magnetic hyperthermia performance. So it can reduce the concentration of magnetic nanoparticles in clinical practice and minimize the side effects in tumor treatment. This review described in detail that how to optimize the modulation of magnetic nanoparticles to improve magnetic hyperthermia performances.