Function and Significance of EBV-encoded miRNAs in Viral Infection and Oncogenesis

doi:10.16476/j.pibb.2019.0090

Home > Archive>Volume 46, Issue 8, 2019 >787-795. DOI:10.16476/j.pibb.2019.0090

Function and Significance of EBV-encoded miRNAs in Viral Infection and Oncogenesis
DOI:
                        10.16476/j.pibb.2019.0090
                    
Author:
                        
                        
                    
Affiliation:1.Cancer Research Institute, University of South China, Hengyang 421001, China;2.Experimental Center for Medical Research, University of South China, Hengyang 421001, China
Clc Number:
Fund Project:This work was supported by grants from The National Natural Science Foundation of China(81372134, 81641012).

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Epstein-Barr virus (EBV) has a relatively large double-stranded DNA genome. The EBV genome is approximately 172 kb in length. EBV has been associated with several cancer types, such as nasopharyngeal carcinoma, lymphoma and gastric cancer. EBV miRNAs can regulate gene expressions of virus and host cell, and play a variety of roles in the development of EBV-associated cancers. This article reviews the biological functions of EBV miRNAs in viral infection, oncogenesis, tumor invasion and metastasis, anti-apoptosis, signaling pathway, and potential significance as biomarkers for diagnosis of EBV-associated cancers. EBV miRNAs may be candidate targets of the therapy for EBV-associated cancers.

Reference

Cited by

Get Citation

PENG Qiu, LIU Liang-Zhuan, GAN Run-Liang. Function and Significance of EBV-encoded miRNAs in Viral Infection and Oncogenesis[J]. Progress in Biochemistry and Biophysics,2019,46(8):787-795

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

History

Received:April 23,2019
Revised:June 18,2019
Accepted:July 02,2019
Online: November 05,2019
Published: August 20,2019

Get Citation

Share

Article Metrics

History