As a kind of mechanical vibration wave, ultrasonic has ripple effect, mechanical effect and thermal effect，all of which have significant application value in clinical. Thus it can be used for diagnosis of disease, auxiliary dosage, regulation and thermal ablation etc. Ultrasonic techniques of non-invasive, strong penetrating power and high spatial resolution characteristics, also make it is widely applied in the diagnosis and treatment of disease of the nervous system. Depression, a common psychiatric disorder, is facing great challenges in diagnosis and treatment. A large number of researchers have applied ultrasonic technology in depression. This review mainly summarized the application of ultrasonic technology in depression in recent ten years from the aspects of ultrasonic imaging, ultrasonic fixed-point drug delivery, ultrasonic regulation and ultrasound-induced depression, hoping to provide certain reference and help for the study of the pathogenesis, diagnosis and treatment of depression.