Research Progress In Necroptosis

doi:10.16476/j.pibb.2019.0209

Home > Archive>Volume 47, Issue 7, 2020 >561-573. DOI:10.16476/j.pibb.2019.0209

Research Progress In Necroptosis
DOI:
                        10.16476/j.pibb.2019.0209
                    
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Affiliation:1.1)Department of Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;2.2)National Center for Liver Cancer, Shanghai 201805, China;3.3)The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
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Fund Project:The National Natural Science Foundation of China

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Abstract:

Programmed cell death is critical for maintenance cellular organisms homeostasis. Necroptosis is a recently identified mode of programmed cell death that morphologically similar to necrosis. Necroptosis is mediated by Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and its substrate Mixed lineage kinase domain-like protein（MLKL）. It has been shown that necroptosis is related to several human diseases, such as inflammatory diseases, autoimmune diseases, tumors and degenerative diseases. In this review, we will discuss the molecular mechanisms of necroptosis and its associated diseases.

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shi shennan, Qin xia, Wang hongyang, Cai zhenyu. Research Progress In Necroptosis[J]. Progress in Biochemistry and Biophysics,2020,47(7):561-573

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Received:September 06,2019
Revised:October 25,2019
Accepted:June 17,2020
Online: October 26,2020
Published: July 20,2020

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