1.1)Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China;2.2)Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China;3.3)Center of Systems Biology and Human Health, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China;4.4)State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

This work was supported by grants from The National Natural Science Foundation of China (31922088), Research Grant Council (N_HKUST606/17, 26102719, C6002-17GF, C7065-18GF, R4017-18) and Innovation and Technology Commission (ITCPD/17-9, ITS/480/18FP).