Research Progress on Transmembrane Transport Mechanisms for the Main Components of the Outer Membrane in Gram-negative Bacteria

doi:10.16476/j.pibb.2020.0022

Home > Archive>Volume 47, Issue 6, 2020 >510-522. DOI:10.16476/j.pibb.2020.0022

Research Progress on Transmembrane Transport Mechanisms for the Main Components of the Outer Membrane in Gram-negative Bacteria
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                        10.16476/j.pibb.2020.0022
                    
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Affiliation:1.1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;2.2)College of Fisheries and Life Sciences, Shanghai Ocean University, Shanghai 201306, China;3.3)Laboratory of Quality & Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China;4.4)Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China
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Fund Project:This work was supported by grants from The National Natural Science Foundation of China (31972188, 31671779), National Postdoctoral Program for Innovation Talent (BX201901940), Shanghai Post-doctoral Excellence Program (2019348), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-10-E00056), National Key Research and Development Program (2018YFC1602205), Shanghai Agriculture Applied Technology Development Program (T20170404) and China Postdoctoral Science Foundation (2019M661469).

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Abstract:

The outer membrane of Gram-negative bacteria is composed of lipopolysaccharide, phospholipid, β-barrel protein and lipoprotein, which is the primary physical barrier protecting bacterial cell from harmful substances, and associated with bacterial pathogenicity and antibiotic resistance. The components of the outer membrane depend on specific systems for transmembrane transport, including the lipopolysaccharide transport system (Lpt), maintenance of lipid asymmetry (Mla), β-barrel assembly machinery (Bam) and localization of lipoprotein (Lol). These systems can ensure the integrity and stability of the bacterial outer membrane, which play important roles in bacterial growth and survival. Therefore, this review summarized the research progress on structure and function of these transmembrane transport systems in Gram-negative bacteria, and prospected the future research direction, which provided new insights for developing the novel antibiotics.

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TONG Jin-Rong, ZHANG Zhao-Huan, HUANG Zhen-Hua, ZHANG Xu, SHI Jun, LIU Hai-Quan, PAN Ying-Jie, ZHAO Yong. Research Progress on Transmembrane Transport Mechanisms for the Main Components of the Outer Membrane in Gram-negative Bacteria[J]. Progress in Biochemistry and Biophysics,2020,47(6):510-522

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Received:January 15,2020
Revised:April 15,2020
Accepted:April 27,2020
Online: September 22,2020
Published: June 20,2020

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