Drug-induced cardiotoxicity is one of the important causes of the failure in drug development. The traditional animal models for drug evaluation have many defects such as species differences, high cost, and low efficiency. It is crucial for drug development to construct more economical and efficient toxicity evaluation models which can accurately simulate the physiological characteristics of human heart. In recent years, with the rapid development of stem cell and bioprinting technologies, the construction of in vitro cardiac tissue model has received more and more attention. In this review, the origin and development of in vitro cardiac model construction are overviewed. The cell sources of cardiomyocyte and the relative techniques and methods for model construction are comprehensively reviewed. Combining with the construction technologies such as bio-printing and microfluidics,the importance and research progress of vascularized cardiac tissue model are highlighted. Finally, the future perspectives and challenges of this field are discussed in order to provide new ideas for the research and application of in vitro cardiac tissue model in drug evaluation.