Weakening Visual Function Enhances Auditory Fear Conditioning in Mice
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1.1)College of Biological and Environmental Engineering, Binzhou University, Binzhou 256600, China;2.2)Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei 230026, China;3.3)State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;4.4)CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China;5.5)Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;6.6)College of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650200, China;7.7)Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin 541199, China

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This study was supported by grants from the Doctor Foundation of Binzhou University (2016Y18), Major Projects of Binzhou University(2020ZD01), The National Natural Science Foundation of China(31730039), National Key R&D Program of China (2020AAA0105601,2019YFA0707103), The National Science Foundation for Young Scientists of China(81703497), The Strategic Priority Research Program of Chinese Academy of Sciences (XDB32010300, ZDBS-LY-SM028), Guangxi Natural Science Foundation (2020GXNSFAA297134), and Guangxi Science and Technology Base and Talent Special Project (GuiKe-AD20238023).

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    Abstract:

    As advanced cognitive activities, it is poorly understood if visual weakening affects auditory fear conditioning. Here we investigated the responses in auditory Pavlovian fear conditioning, using mutant rd/rd, cl/cl mice as visual weakening group. Freezing behaviors were recorded during fear conditioning, fear extinction, and extinction recall phases. The results indicated that mice with shape vision deprivation are more conducive to auditory fear conditioning. We discuss the possible neuro-mechanism of visual-auditory system interactions.

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FU Juan, ZHAO Xu-Dong, LIU Tian-E, MA Man-Xiu, SUN Hua-Ying, ZHANG Bo, ZHENG Xi-Geng. Weakening Visual Function Enhances Auditory Fear Conditioning in Mice[J]. Progress in Biochemistry and Biophysics,2021,48(6):709-714

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History
  • Received:October 05,2020
  • Revised:April 14,2021
  • Accepted:May 07,2021
  • Online: June 24,2021
  • Published: June 20,2021